Amanda Q. X. Nio

Research Associate at King's College London Department of Biomedical Engineering E-mail: nio@aqxn.info

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My research focuses on cardiovascular physiology — with an emphasis on applying and developing non-invasive methods to gain insights into sex differences, ageing, and adaptations to exercise training.

As a graduate student, I examined sex differences in cardiac function, as well as the impact of the menstrual cycle and menopause on the female heart. I am particularly interested in the functional capacity of the heart; how the heart copes with / responds to physiological stress. To that end, I have successfully assessed cardiac function during acute incremental exercise, during lower body negative pressure, and after 24 weeks of exercise training (longitudinal study). Below is a short video of me describing my research (2012).

I have strong inter-disciplinary interests and have worked with computer scientists and engineers to test the linear relationship between subharmonic emissions from microbubbles (using ultrasound imaging) and ambient pressure. The successful translation of this idea will equip clinicians and scientists with a technique to measure pressure in the left ventricle non-invasively.

Brief vita

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Research

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November, 2014 – present:

Research Assistant in the Cardiac Modelling and Imaging Biomarkers Group , Department of Biomedical Engineering at King's College London, UK

2020:

PhD in Cardiac Exercise Physiology at Cardiff Metropolitan University , UK

March – September, 2016:

Visiting research scholar in the Department of Radiology at Thomas Jefferson University, Philadelphia, PA, USA

October – November, 2011:

Temporary staff at the DSO National Laboratories (Combat Protection and Performance 1), Singapore

2011:

MSc (Distinction) in Sports and Exercise Science at the University of Wales Institute, Cardiff, UK (now Cardiff Metropolitan University )

April, 2007 – September, 2010:

Member of Technical staff at the DSO National Laboratories (Military Physiology Laboratory, Combat Protection and Performance Programme), Singapore

2007:

BSc (Hons) in Chemistry (minor in Business) at the National University of Singapore , Singapore

Publications & Conference Proceedings

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(my profile on Google Scholar )

I had to transfer the copyright for some of the articles listed below to the publishers of the journals in which they appeared. However, I am allowed to distribute copies to individuals for personal and/or research use. Your click on any of the links below constitutes your request to me for a personal copy of the linked article. A detailed copyright notice appears in the articles. Nature's web debates published an interesting relevant article by Richard M. Stallman titled "Science must `push copyright aside´" .

2019

• Nio, A. Q. X., Faraci, A., Christensen-Jeffries, K., Raymond, J. L., Monaghan, M. J., Fuster, D., Forsberg, F., Eckersley, R. J., & Lamata, P. (2020). Optimal Control of SonoVue Microbubbles to Estimate Hydrostatic Pressure. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 67, 557–567.
  • Journal Website
• Gupta, I.^*, Nio, A. Q.X.^*, Faraci, A., Torkzaban, M., Christensen-Jeffries, K., Nam, K., Raymond, J. L., Wallace, K., Monaghan, M. J., Fuster, D., Eckersley, R. J., Lamata, P., & Forsberg, F. (2019). The Effects of Hydrostatic Pressure on the Subharmonic Response of SonoVue and Sonazoid. 2019 IEEE International Ultrasonics Symposium (IUS), Glasgow, United Kingdom, 2019 1349–1352. ^{*Contributed equally.}
  • Journal Website

2018

• Lakens, D., Adolfi, F. G., Albers, C. J., Anvari, F., Apps, M. A. J., Argamon, S. E., … Zwaan, R. A. (2018). Justify Your Alpha. Nature Human Behaviour, 2, 168–171.
  • Preprint on PsyArXiv

2017

• Nio, A. Q. X., Faraci, A., Christensen-Jeffries, K., Eckersley, R. J., Monaghan, M. J., Raymond, J. L., Forsberg, F., & Lamata, P. (2017, September). The subharmonic amplitude of SonoVue increases with hydrostatic pressure at low incident acoustic pressures. In Ultrasonics Symposium (IUS), 2017 IEEE International. IEEE.
• Nio, A. Q. X., Stöhr, E. J., & Shave, R. E. (2017). Age-related differences in left ventricular structure and function between healthy men and women. Climacteric, 20, 476–483.
  • Supplemental Material.

2016

• Liu, J.-B., Nio, A. Q. X., Esposito, C., Chen, J., Zhang, J., Zhong, X., Liu, R., Wang, J., Dai, Z., Forsberg, F., & Dave, J. K. (2016, September). Characterizing the subharmonic response of four new microbubble formulations compared with three commercially-available ultrasound contrast agents. In Ultrasonics Symposium (IUS), 2016 IEEE International. IEEE.

2015

• Nio, A. Q. X., Stöhr, E. J., & Shave, R. (2015). The female human heart at rest and during exercise: A review. European Journal of Sport Science, 15, 286–295.

2014

• Sudsa-ard, K., Kijboonchoo, K., Chavasit, V., Chaunchaiyakul, R., Nio, A. Q. X., & Lee, J. K. W. (2014). Lactose-free milk prolonged endurance capacity in lactose intolerant Asian males. Journal of the International Society of Sports Nutrition, 11, 49.
• Stembridge, M., Ainslie, P. M., Hughes, M. G., Stöhr, E. J. Cotter, J. D., Nio, A. Q. X., & Shave, R. (2014). Ventricular structure, function, and mechanics at high altitude: Chronic remodeling in Sherpa vs. short-term lowlander adaptation. Journal of Applied Physiology, 117 334–343.
• Lee, J. K. W., Koh, A. C. H., Koh, S. X. T., Liu G. J. X., Nio, A. Q. X., & Fan P. W. P. (2014). Neck cooling and cognitive performance following exercise-induced hyperthermia. European Journal of Applied Physiology, 114 375–384.

2013

• Lee, J. K. W., Yeo, Z. W., Nio A. Q. X., Koh, A. C., Teo, Y. S., Goh, L. F., Tan, P. M., & Byrne, C. (2013). Cold drink attenuates heat strain during work-rest cycles. International Journal of Sports Medicine, 34, 1037–1042.

2012

• Yeo, Z. W., Fan, P. W. P., Nio, A. Q. X., Byrne, C., & Lee, J. K. W. (2012). Ice slurry on outdoor running performance in heat. International Journal of Sports Medicine, 33, 859–866.
• Lee, J. K. W., Nio, A. Q. X., Fun, D. C. Y., Teo, Y. S., Chia, E. V., & Lim, C. L. (2012). Effects of heat acclimatisation on work tolerance and thermoregulation in trained tropical natives. Journal of Thermal Biology, 37 366–373.

2011

• Lee, J. K. W., Nio, A. Q. X., Ang, W. H., Johnson, C., Aziz, A. R., Lim, C. L., & Hew-Butler, T. (2011). First reported cases of exercise-associated hyponatremia in Asia. International Journal of Sports Medicine, 32 297–302.
• Lee, J. K. W., Nio, A. Q. X., Ang, W. H., Law, L. Y. L., & Lim, C. L. (2011). Effects of ingesting a sports drink during exercise and recovery on subsequent endurance capacity. European Journal of Sport Science, 11 77–86.

2010

• Lee, J. K. W., Nio, A. Q. X., Lim, C. L., Teo, E. Y. N., & Byrne, C. (2010). Thermoregulation, pacing and fluid balance during mass participation distance running in a warm and humid environment. European Journal of Applied Physiology, 109 887–898.

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Selected colleagues and collaborators:

• Pablo Lamata: Reader in Computational Cardiology at King's College London, UK; Wellcome Trust Senior Research Fellow in Basic Biomedical Science
• Jason K. W. Lee: Lead Physiologist at DSO National Laboratories, Adjunct Associate Professor at National University of Singapore, and Adjunct Assistant Professor at Nanyang Technological University, Republic of Singapore
• Flemming Forsberg: Professor of Radiology at Thomas Jefferson University, Philadelphia, PA, USA
• Eric J. Stöhr: Lecturer in Cardiac Physiology and Health at Cardiff Metropolitan University, UK
• Christoph T. Weidemann: Associate Professor at Swansea University, UK